ISOLATION AND ANTI-YEAST ACTIVITY OF SECONDARY METABOLITES OF SOURSOP LEAF ENDOPHYTIC FUNGI

This study aimed to isolate the endophytic fungi of soursop leaves that have potential as anti-yeast. Soursop were collected from 3 locations in West Java, Indonesia. The secondary metabolites produced by extracted with ethyl acetate and tested for anti-yeast activity against Saccharomyces cerevisiae Candida tropicalis. Profile extracts contents characterization was carried out using thin-layer chromatography (TLC). Twelve monoculture isolates Sukabumi (3 isolates), Cianjur Garut (6 isolates). It showed different abilities inhibit C. tropicalis S. cereviseae. best extract is isolat (Sir-C1) (Sir-S1). stain patterns seen between nine similar. indicates compounds them may also be same. But a absorbance activities. total each are different. TLC results extraction almost same metabolite components extracts, all had an various absorbance. There differences ability 12 leaf yeast model cerevisiae. Some similar profiles, but their not